Viral Diversity Threshold for Adaptive Immunity in Prokaryotes
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Viral Diversity Threshold for Adaptive Immunity in Prokaryotes
UNLABELLED Bacteria and archaea face continual onslaughts of rapidly diversifying viruses and plasmids. Many prokaryotes maintain adaptive immune systems known as clustered regularly interspaced short palindromic repeats (CRISPR) and CRISPR-associated genes (Cas). CRISPR-Cas systems are genomic sensors that serially acquire viral and plasmid DNA fragments (spacers) that are utilized to target a...
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ژورنال
عنوان ژورنال: mBio
سال: 2012
ISSN: 2161-2129,2150-7511
DOI: 10.1128/mbio.00456-12